ANAESTHETiCS’ PHySiologiCAl mECHANiSmS
نویسنده
چکیده
The topic may be approached by defining the concept of anaesthesia, a term introduced by Oliver Wendell Holmes for defining the elimination of surgical pain, characterised by immobility, eliminating pain, amnesia and lack of consciousness, effects provoked by using anaesthetic agents reversibly affecting different areas of the central nervous system (CNS). These conditions were successfully met for the first time on the 16th of October 1846 in the Massachusetts Hospital when Dr. William Morton1 administered ether by inhalatory route to a patient for the removal of a mass from the neck, a landmark for modern medicine, especially in surgical areas. New anaesthetics have been developed since then and attempts made to understand their mechanism of action (MOA) for ascertaining the components of anaesthetics.
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Department of Surgery and Cancer, Anaesthetics, Pain Medicine and Intensive Care Section, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom; Department of Anaesthetics, The Queen Elizabeth Hospital, Birmingham, United Kingdom; Preclinical Compound Profiling, Secondary Pharmacology, Preclinical Safety, NIBR, Cambridge, Massachusetts; Departmen...
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